Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 05/08/2017 | Crawley Town | 1 | 3 | Port Vale | C Breakspear |
| 12/08/2017 | Port Vale | 2 | 3 | Wycombe | C Hicks |
| 19/08/2017 | Chesterfield | 2 | 0 | Port Vale | T Nield |
| 26/08/2017 | Port Vale | 0 | 1 | Crewe | D Handley |
| 02/09/2017 | Port Vale | 0 | 1 | Notts County | R Lewis |
| 09/09/2017 | Coventry | 1 | 0 | Port Vale | B Huxtable |
| 12/09/2017 | Luton | 2 | 0 | Port Vale | D Webb |
| 16/09/2017 | Port Vale | 1 | 1 | Forest Green | M Coy |
| 23/09/2017 | Yeovil | 1 | 1 | Port Vale | G Salisbury |
| 26/09/2017 | Port Vale | 1 | 2 | Accrington | E Ilderton |
| 30/09/2017 | Stevenage | 2 | 0 | Port Vale | C Breakspear |
| 07/10/2017 | Port Vale | 1 | 2 | Grimsby | A Woolmer |
| 14/10/2017 | Port Vale | 3 | 1 | Cheltenham | S Oldham |
| 17/10/2017 | Morecambe | 0 | 3 | Port Vale | R Joyce |
| 21/10/2017 | Exeter | 0 | 1 | Port Vale | C Hicks |
| 28/10/2017 | Port Vale | 0 | 3 | Swindon | G Horwood |
| 10/11/2017 | Newport County | 1 | 1 | Port Vale | J Busby |
| 18/11/2017 | Port Vale | 1 | 0 | Barnet | A Backhouse |
| 21/11/2017 | Port Vale | 0 | 4 | Mansfield | T Kettle |
| 25/11/2017 | Lincoln | 3 | 1 | Port Vale | A Haines |
| 09/12/2017 | Port Vale | 2 | 0 | Cambridge | A Coggins |
| 16/12/2017 | Carlisle | 1 | 2 | Port Vale | M Salisbury |
| 23/12/2017 | Colchester | 1 | 1 | Port Vale | N Kinseley |
| 26/12/2017 | Port Vale | 1 | 0 | Coventry | J Brooks |
| 30/12/2017 | Port Vale | 4 | 0 | Luton | T Nield |
| 01/01/2018 | Notts County | 1 | 0 | Port Vale | D Handley |
| 06/01/2018 | Forest Green | 1 | 0 | Port Vale | K Stroud |
| 13/01/2018 | Port Vale | 1 | 1 | Yeovil | D Webb |
| 20/01/2018 | Accrington | 3 | 2 | Port Vale | R Joyce |
| 27/01/2018 | Port Vale | 2 | 2 | Colchester | T Kettle |
| 03/02/2018 | Port Vale | 0 | 0 | Morecambe | B Toner |
| 10/02/2018 | Cheltenham | 5 | 1 | Port Vale | B Huxtable |
| 17/02/2018 | Swindon | 3 | 2 | Port Vale | A Woolmer |
| 24/02/2018 | Port Vale | 0 | 0 | Newport County | T Nield |
| 10/03/2018 | Grimsby | 1 | 1 | Port Vale | S Stockbridge |
| 13/03/2018 | Barnet | 1 | 1 | Port Vale | B Malone |
| 17/03/2018 | Port Vale | 2 | 2 | Stevenage | A Backhouse |
| 20/03/2018 | Port Vale | 0 | 1 | Exeter | D Whitestone |
| 24/03/2018 | Wycombe | 0 | 0 | Port Vale | L Swabey |
| 30/03/2018 | Port Vale | 2 | 1 | Chesterfield | T Harrington |
| 02/04/2018 | Crewe | 2 | 2 | Port Vale | A Woolmer |
| 07/04/2018 | Port Vale | 1 | 2 | Crawley Town | M Jones |
| 14/04/2018 | Port Vale | 1 | 0 | Lincoln | J Busby |
| 21/04/2018 | Mansfield | 1 | 1 | Port Vale | C Boyeson |
| 28/04/2018 | Port Vale | 1 | 2 | Carlisle | B Toner |
| 05/05/2018 | Cambridge | 5 | 0 | Port Vale | C Hicks |